Synthesis of monophosphoryl lipid A using 2-naphtylmethyl ethers as permanent protecting groups
نویسندگان
چکیده
منابع مشابه
Inefficient TLR4/MD-2 Heterotetramerization by Monophosphoryl Lipid A
Synthetic forms of E. coli monophosphoryl lipid A (sMLA) weakly activate the MyD88 (myeloid differentiation primary response protein) branch of the bifurcated TLR4 (Toll-like receptor 4) signaling pathway, in contrast to diphosphoryl lipid A (sDLA), which is a strong activator of both branches of TLR4. sMLA's weak MyD88 signaling activity is apparent downstream of TLR4/MyD88 signaling as we sho...
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ژورنال
عنوان ژورنال: Carbohydrate Research
سال: 2020
ISSN: 0008-6215
DOI: 10.1016/j.carres.2020.108152